09-874
Anti-SAP30 (yeast) Antibody
from rabbit
别名:
Sin3 corepressor complex subunit SAP30, Sin3-associated polypeptide, 30 kDa, Sin3-associated polypeptide, 30kDa, Sin3A-associated protein, 30kDa, histone deacetylase complex subunit SAP30
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
Saccharomyces cerevisiae
Citations:
6
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
Anti-SAP30 (yeast) Antibody, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
Saccharomyces cerevisiae
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
Saccharomyces cerevisiae ... Sap30(855305)
Analysis Note
Control
Yeast extract
Yeast extract
Western Blot Analysis:
1 μg/ml of this antibody detected SAP30 in a yeast extract.
1 μg/ml of this antibody detected SAP30 in a yeast extract.
Application
Anti-SAP30 (yeast) Antibody is a Rabbit Polyclonal Antibody for detection of SAP30 (yeast) also known as Sin3 corepressor complex subunit SAP30 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Chromatin Biology
Histones
Chromatin Biology
Biochem/physiol Actions
Not tested in other species.
Recognizes yeast SAP30 at ~27 kDa.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
SAP30 (Sin3A-associated protein) is a widely expressed nuclear protein that is functionally conserved between human and yeast. It is a component of the multiprotein histone deacetylase complex containing the transcriptional repressor Sin3, multiple histone deacetylases (HDAC1 and HDAC2), histone binding proteins (RbAp46 and RbAp48) and other polypeptides. SAP30 can recruit the deacetylase complex to promoter DNA in a Sin3 independent manner and is involved in the recruitment of the mSin3 complex to a specific subset of N-CoR corepressor complexes. The latter function suggests a role for SAP30 in N-CoR-mediated repression. Furthermore, SAP30 may be involved in imparting target specificity to the deacetylase complex.
~27 kDa
Immunogen
Epitope: a.a. 141-157
Immunogen was a synthetic peptide corresponding to a.a. 141-157 of yeast SAP30, conjugated to KLH.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein A purified IgG in 0.1M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% NaN3.
Preparation Note
Stable for 1 year at 2-8°C from date of shipment.
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存储类别
10 - Combustible liquids
C D Laherty et al.
Molecular cell, 2(1), 33-42 (1998-08-14)
The transcriptional corepressor mSin3 is found in a large multiprotein complex containing the histone deacetylases HDAC1 and HDAC2, in addition to at least five tightly associated polypeptides. We have cloned and characterized a novel component of the mSin3 complex, SAP30
Y Zhang et al.
Molecular cell, 1(7), 1021-1031 (1998-07-04)
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Recently, histone acetylation and deacetylation were found to be catalyzed by structurally distinct, multisubunit complexes that mediate, respectively, activation and repression of transcription. Here, we identify SAP30
Specific initiation by RNA polymerase I in a whole-cell extract from yeast.
Schultz, M C, et al.
Proceedings of the National Academy of Sciences of the USA, 88, 1004-1008 (1991)
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