100073
15-PGDH Inhibitor
The 15-PGDH Inhibitor controls the biological activity of 15-PGDH. This small molecule/inhibitor is primarily used for Membrane applications.
别名:
15-PGDH Inhibitor, 5-(4-(2-Cyclohexylethoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione
InChI
1S/C19H23NO4S/c1-23-16-11-14(12-17-18(21)20-19(22)25-17)7-8-15(16)24-10-9-13-5-3-2-4-6-13/h7-8,11-13H,2-6,9-10H2,1H3,(H,20,21,22)/b17-12-
InChI key
REFPRDWFDSQKAG-ATVHPVEESA-N
SMILES string
O=C(NC/1=O)SC1=C/C2=CC=C(OCCC3CCCCC3)C(OC)=C2
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL, clear, pale yellow
shipped in
ambient
Quality Level
General description
A cell-permeable, thiazolidinedione derivative that acts as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (IC50 = 25 nM). It is shown to increase PGE2 levels in IL-1β-stimulated A549 cells, dose-dependently, in the range of 0–20 µM, and elicits cochlear blood flow (CBF) increase by 15% and 55% when applied intravenously to 250 g guinea pigs at 10 µg and 20 µg respectively.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Wu, Y., et al. 2011. J. Med. Chem.54, 5260.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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