108975
亮抑酶肽，半硫酸盐，来源于微生物
Leupeptin hemisulfate, CAS 103476-89-7, is a reversible inhibitor of trypsin-like proteases and cysteine proteases
别名:
亮抑酶肽，半硫酸盐，来源于微生物, Ac-LLR-CHO, ½H₂SO₄
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经验公式（希尔记法）:
C20H38N6O4 · 0.5H2SO4
化学文摘社编号:
分子量:
475.59
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.77
质量水平
描述
Merck USA index - 14, 5456
方案
≥90% (HPLC)
表单
lyophilized solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
water: 50 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
[N+H](=C(N)N)CCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)C=O
InChI
1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1
InChI key
GDBQQVLCIARPGH-ULQDDVLXSA-O
一般描述
胰蛋白酶样蛋白酶和半胱氨酸蛋白酶的可逆抑制剂。也已知抑制活化诱导的程序性细胞死亡并恢复HIV+供体的缺陷免疫应答。常用于内蛋白酶Lys-C、激肽释放酶、木瓜蛋白酶、纤溶酶、凝血酶、组织蛋白酶B、胰蛋白酶的抑制。亮肽素不抑制胰凝乳蛋白酶、弹性蛋白酶、肾素或胃蛋白酶。对于大多数应用，建议的工作范围是10-100 µM。
生化/生理作用
主要靶标
胰蛋白酶和半胱氨酸样蛋白酶
胰蛋白酶和半胱氨酸样蛋白酶
产物不与ATP竞争。
可逆性：是
细胞渗透性：否
制备说明
复溶后，等分并冷冻长期保存（-20°C），或冷藏（4°C）短期保存。水性储备溶液在4°C下可稳定保存长达1周，在-20°C下可稳定保存长达1个月。
其他说明
Ac-Leu-Leu-arginal，半硫酸盐
Montenez, J.P., et al. 1994.Toxicol.Lett.73, 201.
Sarin, A., et al. 1994.J. Immunol.153, 862.
Sarin, A., et al. 1994.J. Immunol.153, 862.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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