108976
亮抑酶肽，半硫酸盐，合成
Synthetic version of the microbial-derived inhibitor Leupeptin against trypsin-like and cysteine protease activities.
别名:
亮抑酶肽，半硫酸盐，合成
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关于此项目
经验公式（希尔记法）:
C20H38N6O4 · 0.5H2SO4
化学文摘社编号:
分子量:
475.59
UNSPSC Code:
12352202
NACRES:
NA.21
MDL number:
SMILES string
[N+H](=C(N)N)CCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)C=O
InChI
1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1
InChI key
GDBQQVLCIARPGH-ULQDDVLXSA-O
description
Merck USA index - 14, 5456.
assay
≥95% (sum of isomers, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
off-white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
针对胰蛋白酶样和半胱氨酸蛋白酶活性的微生物衍生抑制剂亮肽素（目录编号108975）的合成形式。
Packaging
用惰性气体包装
Other Notes
Ac-Leu-Leu-arginal，半硫酸盐
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
S Joseph Endicott et al.
The Journal of cell biology, 219(12) (2020-10-14)
Chaperone-mediated autophagy (CMA) is the most selective form of lysosomal proteolysis, where individual peptides, recognized by a consensus motif, are translocated directly across the lysosomal membrane. CMA regulates the abundance of many disease-related proteins, with causative roles in neoplasia, neurodegeneration
Gemma Gou et al.
Journal of neurochemistry, 154(6), 618-634 (2020-02-19)
The SynGAP protein is a major regulator of synapse biology and neural circuit function. Genetic variants linked to epilepsy and intellectual disability disrupt synaptic function and neural excitability. SynGAP has been involved in multiple signaling pathways and can regulate small
Pietri Puustinen et al.
Autophagy, 16(10), 1871-1888 (2020-01-28)
Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breast carcinoma cells and identified the catalytic subunit of
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