108976
亮抑酶肽,半硫酸盐,合成
Synthetic version of the microbial-derived inhibitor Leupeptin against trypsin-like and cysteine protease activities.
别名:
亮抑酶肽,半硫酸盐,合成
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关于此项目
经验公式(希尔记法):
C20H38N6O4 · 0.5H2SO4
CAS Number:
分子量:
475.59
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.21
描述
Merck USA index - 14, 5456.
质量水平
方案
≥95% (sum of isomers, HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
off-white
溶解性
water: 50 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
[N+H](=C(N)N)CCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)C=O
InChI
1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1
InChI key
GDBQQVLCIARPGH-ULQDDVLXSA-O
一般描述
针对胰蛋白酶样和半胱氨酸蛋白酶活性的微生物衍生抑制剂亮肽素(目录编号108975)的合成形式。
包装
用惰性气体包装
其他说明
Ac-Leu-Leu-arginal,半硫酸盐
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性:标准处理(A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Gemma Gou et al.
Journal of neurochemistry, 154(6), 618-634 (2020-02-19)
The SynGAP protein is a major regulator of synapse biology and neural circuit function. Genetic variants linked to epilepsy and intellectual disability disrupt synaptic function and neural excitability. SynGAP has been involved in multiple signaling pathways and can regulate small
S Joseph Endicott et al.
The Journal of cell biology, 219(12) (2020-10-14)
Chaperone-mediated autophagy (CMA) is the most selective form of lysosomal proteolysis, where individual peptides, recognized by a consensus motif, are translocated directly across the lysosomal membrane. CMA regulates the abundance of many disease-related proteins, with causative roles in neoplasia, neurodegeneration
Pietri Puustinen et al.
Autophagy, 16(10), 1871-1888 (2020-01-28)
Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breast carcinoma cells and identified the catalytic subunit of
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