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Merck
CN

108976

Sigma-Aldrich

亮抑酶肽,半硫酸盐,合成

Synthetic version of the microbial-derived inhibitor Leupeptin against trypsin-like and cysteine protease activities.

别名:

亮抑酶肽,半硫酸盐,合成

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关于此项目

经验公式(希尔记法):
C20H38N6O4 · 0.5H2SO4
CAS Number:
分子量:
475.59
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.21
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描述

Merck USA index - 14, 5456.

质量水平

方案

≥95% (sum of isomers, HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

off-white

溶解性

water: 50 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

[N+H](=C(N)N)CCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)C=O

InChI

1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1

InChI key

GDBQQVLCIARPGH-ULQDDVLXSA-O

一般描述

针对胰蛋白酶样和半胱氨酸蛋白酶活性的微生物衍生抑制剂亮肽素(目录编号108975)的合成形式。

包装

用惰性气体包装

其他说明

Ac-Leu-Leu-arginal,半硫酸盐

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

毒性:标准处理(A)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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The SynGAP protein is a major regulator of synapse biology and neural circuit function. Genetic variants linked to epilepsy and intellectual disability disrupt synaptic function and neural excitability. SynGAP has been involved in multiple signaling pathways and can regulate small
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The Journal of cell biology, 219(12) (2020-10-14)
Chaperone-mediated autophagy (CMA) is the most selective form of lysosomal proteolysis, where individual peptides, recognized by a consensus motif, are translocated directly across the lysosomal membrane. CMA regulates the abundance of many disease-related proteins, with causative roles in neoplasia, neurodegeneration
Pietri Puustinen et al.
Autophagy, 16(10), 1871-1888 (2020-01-28)
Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breast carcinoma cells and identified the catalytic subunit of

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