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Merck
CN

110175-M

Acetyl-Pepstatin

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7).

别名:

Acetyl-Pepstatin, Ac-Val-Val-(3S,4S)-Sta-Ala-(3S,4S)-Sta-OH

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关于此项目

经验公式（希尔记法）:
C31H57N5O9
化学文摘社编号:
28575-34-0
分子量:
643.81
MDL number:
MFCD00214071
UNSPSC Code:
12352202
NACRES:
NA.77

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form

solid

SMILES string

N([C@H]([C@@H](O)CC(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](O)CC(=O)O)CC(C)C)CC(C)C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)C(C)C)C(C)C

InChI

1S/C31H57N5O9/c1-15(2)11-21(35-30(44)28(18(7)8)36-31(45)27(17(5)6)33-20(10)37)23(38)13-25(40)32-19(9)29(43)34-22(12-16(3)4)24(39)14-26(41)42/h15-19,21-24,27-28,38-39H,11-14H2,1-10H3,(H,32,40)(H,33,37)(H,34,43)(H,35,44)(H,36,45)(H,41,42)/t19-,21-,22-,23-,24-,27-,28-/m0/s1

InChI key

WKYBEGDEGRCZNF-LBTYKNIQSA-N

assay

≥97% (HPLC)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

50% acetic acid: 5 mg/mL

storage temp.

−20°C

Quality Level

100

General description

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7). Acts as a substrate-analog inhibitor.

Biochem/physiol Actions

Primary Target
HIV-1 proteinase
Target Ki: 20 nM at pH 4.7 against HIV-1 proteinase

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Ulrich, B., et al. 2000. Protein Sci.9, 2232.
Song, K., et al. 1992. Kidney Int.42, 639.
Richards, A.D., et al. 1989. FEBS Lett. 247, 113.
Richards, A.D., et al. 1989. FEBS Lett. 253, 214.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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