产品名称
ADP-HPD，二水合物，铵盐, ADP-HPD, Dihydrate is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
ADP-核糖的氨基类似物，可作为聚（ADP-核糖）糖水解酶（PARG；IC50=120 nM）的高效，非竞争性和特异性抑制剂。即使在1 mM浓度下，也不会影响聚（ADP-核糖）聚合酶（PARP）或NAD：精氨酸单（ADP-核糖基）-转移酶A的活性。还可作为在更高浓度（IC50 = 260 µM）下来自金环蛇毒液的NAD糖水解酶的抑制剂。注意：1组 = 5 x 60 µg.
注意：1组 = 5 x 60 µg
Biochem/physiol Actions
主要靶标
PARG
PARG
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：120 nM抗聚（ADP-核糖）糖水解酶（PARG）
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并在-20°C下冷冻。储备溶液在-20°C下可稳定保存1周。
Other Notes
Vispe, S., et al. 2000.Proc.Natl.Acad.Sci. USA97, 9886.
Slama, J.T., et al. 1995.J. Med. Chem.38, 389.
Slama, J.T., et al. 1995.J. Med. Chem.38, 4332.
Slama, J.T., et al. 1995.J. Med. Chem.38, 389.
Slama, J.T., et al. 1995.J. Med. Chem.38, 4332.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Shiori Kuraoka et al.
Molecular & cellular proteomics : MCP, 100153-100153 (2021-10-01)
Mass spectrometry-enabled ADP-ribosylation workflows are developing rapidly, providing researchers a variety of ADP-ribosylome enrichment strategies and mass spectrometric acquisition options. Despite the growth spurt in upstream technologies, systematic ADP-ribosyl (ADPr) peptide mass spectral annotation methods are lacking. HCD-dependent ADP-ribosylome studies
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