118490
ATIC Dimerization Inhibitor
别名:
ATIC Dimerization Inhibitor, AMPK Signaling Activator XI, Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI
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关于此项目
经验公式（希尔记法）:
C21H33N7O5
化学文摘社编号:
分子量:
463.53
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥97% (HPLC)
form
solid
potency
691 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: soluble
shipped in
wet ice
Quality Level
General description
A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 240 nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24 hours) compared to AICA-riboside (Cat. No. 123040).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
ATIC
ATIC
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ac-Arg-Ph(4-NO2)-NEt2
Spurr, I.B., et al. 2012. ChemBioChem13, 1628.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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