119137
CGS-21680 hydrochloride hydrate
≥96% (HPLC), solid, adenosine A2A receptor agonist, Calbiochem®
别名:
腺苷A2A受体激动剂I，CGS 21680，盐酸盐, CGS-21680，CGS21680，3-（4-（2-（（6-氨基-9-（（2R,3R,4S,5S）-5-（乙基氨甲酰基）-3,4-二羟基四氢呋喃-2-基）-9H-嘌呤-2-基）氨基）乙基）苯基）丙酸
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关于此项目
经验公式（希尔记法）:
C23H29N7O6 · xHCl
化学文摘社编号:
分子量:
499.52 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥96% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
产品名称
腺苷A2A受体激动剂I，CGS 21680，盐酸盐,
assay
≥96% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM
shipped in
ambient
storage temp.
−20°C
SMILES string
[n]2(c3nc(nc(c3nc2)N)NCCc4ccc(cc4)CCC(=O)O)C1O[C@@H]([C@H]([C@H]1O)O)C(=O)NCC
InChI
1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22?/m0/s1
InChI key
PAOANWZGLPPROA-OFRRTHGGSA-N
General description
CGS 21680是一种强效腺苷A2A受体激动剂（Ki = 27 nM）和黄嘌呤衍生物。CGS 21680 HCl对A2B受体的亲和力较低（Ki = 67 nM），但对A1R（Ki = 290 nM）和A3R（88.8 µM）具有更高的选择性。在慢性炎症期间发挥抗炎作用，并改善与胶原诱导的关节炎相关的组织损伤。显示减少THP1巨噬细胞中CCR7蛋白的表达。在亨廷顿′病的小鼠模型中显示可延缓运动能力的进行性恶化并防止脑重的减少。
Features and Benefits
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ChemiSphere™ App for Digital Data Transfer to OMNIS Titration Instruments from Metrohm
Discover the ChemiSphere™ App for secure, rapid data transfer to OMNIS titrators, enhancing efficiency in the titration workflow with Titripur® and Aquastar®reagents. ChemiSphere™ App for Digital Reagent Data Transfer
SmartChemicals for Digital Data Transfer to Mettler Toledo Titration Instruments
Explore digital data transfer with our SmartChemicals for Mettler Toledo titrators—fast, easy, and safe, accelerating the titration process with Titripur®, Aquastar® reagents, and Certipur® and Aquastar®standards. Supelco® SmartChemicals for Titration
Packaging
用惰性气体包装
Physical form
以盐酸盐形式提供。
Preparation Note
在复溶后，分装并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Other Notes
由于含水量不同，CGS 21680盐酸盐这种化合物的分子量因批次而异。有关特定批次的分子量信息，请参阅小瓶标签或分析证书。所提供的分子量代表无水的基线分子量。
Legal Information
AQUASTAR is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIPUR is a registered trademark of Merck KGaA, Darmstadt, Germany
ChemiSphere is a trademark of Merch KGaA, Darmstadt, Germany
Supelco is a registered trademark of Merck KGaA, Darmstadt, Germany
Titripur is a registered trademark of Merck KGaA, Darmstadt, Germany
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable