121767
AG 1024
A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity.
别名:
AG 1024, 3-Bromo-5- t-butyl-4-hydroxy-benzylidenemalonitrile
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关于此项目
经验公式（希尔记法）:
C14H13BrN2O
化学文摘社编号:
分子量:
305.17
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
Brc1c(c(cc(c1)C=C(C#N)C#N)C(C)(C)C)O
InChI
1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3
InChI key
ABBADGFSRBWENF-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white to yellow
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases with significantly lower IC50 values for IGF-1 than for insulin receptors. Induces apoptosis by downregulating the expression of phospho-Akt1 and Bcl-2; and increasing the expression of Bax, p53 and p21. Reported to enhance the radiosensitivity of human breast cancer cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
IGF-1
IGF-1
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
Other Notes
Wen, B., et al. 2001. Br. J. Cancer85, 2017.
Parrizas, M., et al. 1997. Endocrinology138, 1427.
Ohmichi, M., et al. 1993. Biochemistry32, 4650.
Parrizas, M., et al. 1997. Endocrinology138, 1427.
Ohmichi, M., et al. 1993. Biochemistry32, 4650.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
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