123041
AICA-核糖甙, 5′-磷酸盐
A 5′-phosphorylated analog of membrane permeable AICA-Riboside that mimics AMP and acts as an activator of AMPK (AMP-activated protein kinase).
别名:
AICA-核糖甙, 5′-磷酸盐
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关于此项目
经验公式（希尔记法）:
C9H15N4O8P
化学文摘社编号:
分子量:
338.21
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white to light pink
solubility
water: 1 mg/mL, DMSO: 30 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
[P](=O)(OCC1OC(C(C1O)O)[n]2cnc(c2N)C(=O)N)(O)O
InChI
1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)
InChI key
NOTGFIUVDGNKRI-UHFFFAOYSA-N
General description
膜渗透性AICA-核糖苷（目录编号123040）的5′-磷酸化类似物，模拟AMP并充当AMPK（AMP激活的蛋白激酶）的激活剂。
Biochem/physiol Actions
主要靶标
AMPK（AMP激活的蛋白激酶）的激活剂
AMPK（AMP激活的蛋白激酶）的激活剂
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Packaging
用惰性气体包装
Preparation Note
在复溶后，分装并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
大面积加热后仅具有水溶性。
Other Notes
Fryer, L.G.D., et al. 2002.Biochem.J.363, 167.
Henin, N., et al. 1996.Biochim.Biophys.Acta1290, 197.
Corton, J.M., et al. 1995.Eur. J. Biochem.229, 558.
Sullivan, J.E., et al. 1994.Biochem.Biophys.Res. Commun.200, 1551.
Sabina, R.L., et al. 1985.J. Biol. Chem.260, 6107.
Henin, N., et al. 1996.Biochim.Biophys.Acta1290, 197.
Corton, J.M., et al. 1995.Eur. J. Biochem.229, 558.
Sullivan, J.E., et al. 1994.Biochem.Biophys.Res. Commun.200, 1551.
Sabina, R.L., et al. 1985.J. Biol. Chem.260, 6107.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable