产品名称
Akt抑制剂, The Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
assay
≥98% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white to off-white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
靶标IC50：对于Akt (PKB)，5.0 µM
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
Disclaimer
毒性：标准处理（A）
General description
一种具有细胞可渗透性、可逆性和底物竞争性的磷脂酰肌醇醚类似物，可有效和选择性地抑制Akt(PKB)（IC50为5.0 µM）。中度抑制PI 3-K活性（IC50 = 83.0 µM）。也抑制各种癌症细胞系的生长，IC50值在1-10 µM范围内。
Other Notes
Hu, Y., et al. 2000 J. Med. Chem.43, 3045.
Packaging
用惰性气体包装
Preparation Note
使用无水DMSO进行复溶。
在复溶后，分装并冷冻保存（-20°C）。储备液可在-20°C最长稳定3周。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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