124014
Akt Inhibitor VII, TAT-Akt-in
The Akt Inhibitor VII, TAT-Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Akt Inhibitor VII, TAT-Akt-in, H- YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL110-24, H-YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL110-24
产品名称
Akt Inhibitor VII, TAT-Akt-in, The Akt Inhibitor VII, TAT-Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Target IC50: 50 µM against Akt
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
Other Notes
H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
General description
A cell-permeable and reversible version of the Akt Inhibitor VI, Akt-in (Cat. No. 124013) fused with the protein transduction domain TAT that displays antitumor properties. Inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~50 µM) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells, and tumor growth in syngeneic C57BL/6 mice.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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