Akt Inhibitor IV

A cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 625 nM) and cell proliferation (IC₅₀<1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K.

Cell permeable: yes

Primary Target
Akt

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 625 nM and <1.25 µM in blocking Akt-mediated FOXO1a nuclear export and cell proliferation, respectively, in 786-O cells

Packaged under inert gas

Please refer to vial label for lot-specific concentration.

A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.

Following initial use, aliquot and refrigerate (4°C).

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Irritant (B)