124029
Akt Inhibitor XII, Isozyme-Selective, Akti-2
The Akt Inhibitor XII, Isozyme-Selective, Akti-2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Akt Inhibitor XII, Isozyme-Selective, Akti-2, 1-((2-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl and, 1-((3-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinoxalinyl
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关于此项目
经验公式（希尔记法）:
C39H39N7O2 · 3HCl
分子量:
747.16
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (mixture of regioisomers, HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥97% (mixture of regioisomers, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
yellow
solubility
DMSO: 25 mg/mL, water: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable Akti-1/2- (Cat. No. 124018) derived allosteric inhibitor pair (1:1 regioisomeric mixture) with much improved aqueous solubility (10 mg/ml in a pH 7.4 saline) and Akt2 selectivity (IC50 = 805 nM for Akt2, >10 µM for Akt1/3, and >50 µM for PKA/PKC/SGK). The inhibition is PH domain-dependent and non-competitive with ATP.
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable