124030
Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2
The Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2, N-(2-(Diethylamino)ethyl)-3-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinolinecarboxamide, 3HCl, N-(2-(Diethylamino)ethyl)-2-(4-((4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phe
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关于此项目
经验公式（希尔记法）:
C40H43N7O2 · 3HCl
分子量:
763.20
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (mixture of regioisomers, HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥97% (mixture of regioisomers, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
yellow
solubility
DMSO: 25 mg/mL, water: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) that acts as a plecktrin homology (PH)-domain dependent, non-ATP competitive and an allosteric inhibitor of Akt1/2 (IC50 = 560 nM, 390 nM and 7.8 µM in in vitro kinase assay; 526 nM, 730 nM and >10 µM in LNCaP cells for Akt1, Akt2 and Akt3, respectively) with ~ 80-fold greater selectivity over PKA, PKC and SGK (IC50 >50 µM). One of its potent regioisomers (C7-substituted) is shown to enhance induced caspase-3 activity in several tumor cells.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Zhao, Z., et al. 2008. Bioorg. Med. Chem. Lett.18, 49.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Md Naushad Akhtar et al.
PLoS pathogens, 16(12), e1009136-e1009136 (2020-12-29)
The level of CD40 expression on dendritic cells (DCs) plays a decisive role in disease protection during Leishmania donovani (LD) infection. However, current understanding of the molecular regulation of CD40 expression remains elusive. Using molecular, cellular and functional approaches, we
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 124030-2MG | 04055977205770 |