124038
InSolution Akt 抑制剂 V，曲西立滨-CAS 35943-35-2-Calbiochem
InSolution, ≥95%
别名:
InSolution Akt Inhibitor V, Triciribine
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关于此项目
经验公式（希尔记法）:
C13H16N6O4
化学文摘社编号:
分子量:
320.30
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
InSolution Akt 抑制剂 V，曲西立滨-CAS 35943-35-2-Calbiochem, InSolution, ≥95%
SMILES string
[n]2(c3ncnc4c3c(c2)C(=N)NN4C)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
InChI
1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
InChI key
HOGVTUZUJGHKPL-HTVVRFAVSA-N
description
RTECS - RY8455000
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
shipped in
ambient
storage temp.
−70°C
Quality Level
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相关类别
Disclaimer
Toxicity: Irritant (B)
General description
A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
Other Notes
Karst, A., et al. 2006. Cancer Res.66, 9225.
Yang, L., et al. 2004. Cancer Res.64, 4394.
Yang, L., et al. 2004. Cancer Res.64, 4394.
Packaging
Packaged under inert gas
Preparation Note
Following intitial thaw, aliquot and freeze (-70°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Physical form
A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012 ) in DMSO.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
Jennifer Furkel et al.
Cell reports. Medicine, 2(11), 100436-100436 (2021-11-30)
Cellular morphology has the capacity to serve as a surrogate for cellular state and functionality. However, primary cardiomyocytes, the standard model in cardiovascular research, are highly heterogeneous cells and therefore impose methodological challenges to analysis. Hence, we aimed to devise
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