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Merck
CN

124038

Sigma-Aldrich

InSolution Akt 抑制剂 V,曲西立滨-CAS 35943-35-2-Calbiochem

InSolution, ≥95%

别名:

InSolution Akt Inhibitor V, Triciribine

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关于此项目

经验公式(希尔记法):
C13H16N6O4
化学文摘社编号:
分子量:
320.30
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平

描述

RTECS - RY8455000

方案

≥95% (HPLC)

表单

liquid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

运输

ambient

储存温度

−70°C

SMILES字符串

[n]2(c3ncnc4c3c(c2)C(=N)NN4C)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO

InChI

1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1

InChI key

HOGVTUZUJGHKPL-HTVVRFAVSA-N

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一般描述

A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).

包装

Packaged under inert gas

外形

A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.

制备说明

Following intitial thaw, aliquot and freeze (-70°C).

其他说明

Karst, A., et al. 2006. Cancer Res.66, 9225.
Yang, L., et al. 2004. Cancer Res.64, 4394.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Irritant (B)

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

闪点(°C)

87 °C - closed cup - (Dimethylsulfoxide)


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Jennifer Furkel et al.
Cell reports. Medicine, 2(11), 100436-100436 (2021-11-30)
Cellular morphology has the capacity to serve as a surrogate for cellular state and functionality. However, primary cardiomyocytes, the standard model in cardiovascular research, are highly heterogeneous cells and therefore impose methodological challenges to analysis. Hence, we aimed to devise

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