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Merck
CN

12-439

视网膜母细胞瘤蛋白(aa 773-928)

Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.

别名:

Rb蛋白, 视网膜母细胞瘤蛋白

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关于此项目

UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Form:
liquid
Recombinant:
expressed in E. coli
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产品名称

视网膜母细胞瘤蛋白(aa 773-928), Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.

recombinant

expressed in E. coli

form

liquid

manufacturer/tradename

Upstate®

concentration

2.0 mg/mL

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Quality Level

Gene Information

human ... RB1(5925)

Analysis Note

常规评估为许多丝氨酸/苏氨酸激酶的底物。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Physical form

50 mM Tris-HCl(pH 7.5),150 mM NaCl和500 mM 咪唑

Preparation Note

自收到之日起在-20°C可稳定保存1年。 分装保存以避免反复冻融。

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardCorrosion

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Alberto Viera et al.
Journal of cell science, 128(1), 88-99 (2014-11-09)
In most organisms, telomeres attach to the nuclear envelope at the onset of meiosis to promote the crucial processes of pairing, recombination and synapsis during prophase I. This attachment of meiotic telomeres is mediated by the specific distribution of several
Huikun Zhang et al.
PLoS computational biology, 15(8), e1006813-e1006813 (2019-08-06)
Prediction of compounds that are active against a desired biological target is a common step in drug discovery efforts. Virtual screening methods seek some active-enriched fraction of a library for experimental testing. Where data are too scarce to train supervised
Severine Isabelle Gharbi et al.
NPJ breast cancer, 8(1), 126-126 (2022-11-30)
Despite the biological and therapeutic relevance of CDK4/6 for the treatment of HR+, HER2- advanced breast cancer, the detailed mode of action of CDK4/6 inhibitors is not completely understood. Of particular interest, phosphorylation of CDK4 at T172 (pT172) is critical
Michael J O'Connor et al.
Oncogene, 40(30), 4872-4883 (2021-06-24)
Cyclin D1 is an essential regulator of the G1-S cell-cycle transition and is overexpressed in many cancers. Expression of cyclin D1 is under tight cellular regulation that is controlled by many signaling pathways. Here we report that PARP14, a member
Xueqian Gong et al.
Cancer cell, 32(6), 761-776 (2017-12-13)
Most cancers preserve functional retinoblastoma (Rb) and may, therefore, respond to inhibition of D-cyclin-dependent Rb kinases, CDK4 and CDK6. To date, CDK4/6 inhibitors have shown promising clinical activity in breast cancer and lymphomas, but it is not clear which additional

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