126855
Alendronate, Sodium Salt
≥98% (NMR), farnesyl disphosphate synthase inhibitor, solid
别名:
Alendronate, Sodium Salt, Alendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
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关于此项目
经验公式（希尔记法）:
C4H12NNaO7P2 · 3H2O
化学文摘社编号:
分子量:
325.12
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Alendronate, Sodium Salt, An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.
SMILES string
[Na+].[P](=O)([O-])(O)[C@@]([P](=O)(O)O)(O)CCCN.O.O.O
InChI
1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
InChI key
DCSBSVSZJRSITC-UHFFFAOYSA-M
description
Merck USA index - 14, 229
assay
≥98% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 10 mg/mL
shipped in
ambient
Quality Level
General description
An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts. Shown to induce apoptosis of osteoclasts and macrophages. Inhibits farnesyl disphosphate synthase (IC50 = 460 nM with purified enzyme and 1.7 µM with cell extracts). Also shown to inhibit migration, cell adhesion, and invasion of cells (IC50 = 1 pM in prostate cancer cell invasion assays). Efficiently chelates metal ions and functions as a matrix metalloprotease (MMP) inhibitor (IC50 = 40-70 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Farnesyl diphosphate synthase
Farnesyl diphosphate synthase
Product does not compete with ATP.
Reversible: no
Target IC50: 460 nM against farnesyl diphosphate synthase; ~ 40 - 70 µM as as a broad-spectrum MMP inhibitor; ~ 1 pM against in vitro invasion of prostate cancer cells
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Lehenkari, P.P., et al. 2002. Mol. Pharmacol.62, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys.373, 231.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys.373, 231.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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