138000
D-Amino Acid Oxidase Inhibitor
The D-Amino Acid Oxidase Inhibitor, also referenced under CAS 39793-31-2, controls the biological activity of D-Amino Acid Oxidase.
别名:
D-Amino Acid Oxidase Inhibitor, 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8
InChI key
PMHDSACGRKBACK-UHFFFAOYSA-N
InChI
1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10)
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
beige
solubility
5% NaOH: 25 mg/mL, DMSO: 80 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
Packaging
Packaged under inert gas
Preparation Note
Unstable in solution; reconstitute just prior to use.
Other Notes
Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther.328, 921.
Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett.18, 3386.
Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett.18, 3386.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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