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COA分析证书/COQ

14-306-M

GSK3β 蛋白，活性，10 µg

Name: GSK3β 蛋白，活性，10 µg
Brand: MM

Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.

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eCl@ss:

32160405

NACRES:

NA.26

生物来源

human

质量水平

100

重组

expressed in baculovirus infected Sf21 cells

形式

liquid

分子量

M_w 51 kDa

组成

mercaptoethanol, 0.1-1%
saccharose, 5-10%

manufacturer/tradename

Upstate^®

储存条件

(Tightly closed)

technique(s)

activity assay: suitable (kinase)

溶解性

water: soluble

一般描述

糖原合成酶激酶3β(GSK3β)是丝氨酸-苏氨酸类激酶，分布于大部分真核细胞中。GSK3β基因位于人染色体3q13.3。GSK3β由N端β折叠片结构域与C端α螺旋结构域相连而成。

研究领域：细胞信号传导

生化/生理作用

糖原合成酶激酶3β(GSK3β)通过胰岛素依赖性通路调节糖原代谢。参与无数信号传导通路，包括细胞周期、细胞增殖和发炎等细胞过程。GSK3β介导胰岛素信号通路的负性调节，最终导致2型糖尿病。GSK3β可作为肿瘤抑制剂，抑制细胞的肿瘤转化。它是Wnt/β-连环蛋白传导通路的关键调节因子。GSK3β调节异常与心血管疾病、双相障碍和神经退行性疾病有关。

包装

也提供250 μg的规格（2x125μg）-订购250 μg的规格时，请致电咨询价格和供货情况，参考目录号14-306M。

质量

通过磷酸糖原合酶肽2的磷酸化进行常规评估。

其他说明

比活相关数据，请参阅检验报告以获取该酶的单独批次。

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

抑制剂

产品编号

说明

价格

A2786

腺嘌呤, BioReagent, suitable for cell culture

A5665

腺嘌呤, BioReagent, suitable for plant cell culture, ≥99%

E2250

鞣花酸, ≥95% (HPLC), powder, from tree bark

1369000

碳酸锂, United States Pharmacopeia (USP) Reference Standard

62470

碳酸锂, puriss. p.a., ACS reagent, reagent (for microscopy), ≥99.0% (T)

抗体

产品编号

说明

价格

G7914

Anti-Glycogen Synthase Kinase-3β (GSK-3β) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

WH0002932M4

Monoclonal Anti-GSK3B antibody produced in mouse, clone 1H3, purified immunoglobulin, buffered aqueous solution

GW22779

Anti-GSK3b antibody produced in chicken, affinity isolated antibody, buffered aqueous solution

SAB2100978

Anti-GSK3B antibody produced in rabbit, affinity isolated antibody

HPA028017

抗-GSK3B 兔抗, affinity isolated antibody, buffered aqueous glycerol solution

SAB4300001

抗-磷酸化-GSK3B (pSer⁹) 兔抗, affinity isolated antibody

SAB4300237

Anti-phospho-GSK3B (pTyr²¹⁶) antibody produced in rabbit, affinity isolated antibody

SAB4300287

Anti-GSK3B (Ab-9) antibody produced in rabbit, affinity isolated antibody

SAB5300175

Monoclonal Anti-GSK3B antibody produced in mouse, clone 3D10, ascites fluid

MABN2465

Anti-nonphospho-Ser9/21 GSK3β/α Antibody, clone 15C2, clone 15C2, from mouse

361527

PhosphoDetect Anti-GSK3β (pSer⁹) Mouse mAb (2D3), liquid, clone 2D3, Calbiochem^®

04-903

Anti-GSK3α/β Antibody, rabbit monoclonal, culture supernatant, from rabbit

05-643

抗磷酸化-GSK3β（Ser9）抗体，克隆2D3, clone 2D3, Upstate^®, from mouse

MABN2443

Anti-nonphospho-GSK3 (Ser9) Antibody, beta specific Antibody, clone 12B2, clone 12B2, from mouse

07-1413

Anti-GSK-3b Antibody, a.a. 335-349, from rabbit, purified by affinity chromatography

SAB5700299

Anti-Phospho-GSK3B-S9 antibody produced in rabbit

SAB5700343

Anti-Phospho-GSK3B-Y216 antibody produced in rabbit

SAB5700380

Anti-Phospho-GSK3B-Y216 + GSK3A-Y279 antibody produced in rabbit

SAB5701878

Anti-Phospho-GSK3β-S9 antibody produced in rabbit

ZRB1557

Anti-phospho-GSK3β Ser9 Antibody, clone 6K18 ZooMAb^® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells

G4296

GSK3β活性、His 标记人, PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

SRP0356

GSK3β，活性，人, recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

APREST78016

PrEST Antigen GSK3B, Prestige Antigens^™ Powered by Atlas Antibodies, buffered aqueous solution

14-306-M

GSK3β 蛋白，活性，10 µg, Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.

象形图

GHS07

警示用语：

Warning

危险声明

H317

预防措施声明

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

危险分类

Skin Sens. 1

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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索取COA

GSK3beta: role in therapeutic landscape and development of modulators.

S Phukan et al.

British journal of pharmacology, 160(1), 1-19 (2010-03-25)

Glycogen synthase kinase-3 beta (GSK3beta) is a multifunctional serine/threonine kinase which was originally identified as a regulator of glycogen metabolism. It plays a key role in the regulation of numerous signalling pathways including cellular process such as cell cycle, inflammation

The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro.

Sutherland, C and Cohen, P

Febs Letters, 338, 37-42 (1994)

Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase

Xu, J., et al

The Journal of Biological Chemistry, 278, 26929-26937 (2003)

rystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

Dajani R, et al.

Cell, 105(6), 721-732 (2009)

Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.

Jia Luo

Cancer letters, 273(2), 194-200 (2008-07-09)

Glycogen synthase kinase 3beta (GSK3beta), a multifunctional serine/threonine kinase found in all eukaryotes, had been initially identified as a key regulator of insulin-dependent glycogen synthesis. It is now known that GSK3beta functions in diverse cellular processes including proliferation, differentiation, motility

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