14-306-M
GSK3β 蛋白，活性，10 µg
Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.
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关于此项目
UNSPSC Code:
12352202
NACRES:
NA.26
eCl@ss:
32160405
Form:
liquid
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
Mol wt:
Mw 51 kDa
产品名称
GSK3β 蛋白，活性，10 µg, Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.
biological source
human
recombinant
expressed in baculovirus infected Sf21 cells
form
liquid
mol wt
Mw 51 kDa
composition
mercaptoethanol, 0.1-1%
saccharose, 5-10%
manufacturer/tradename
Upstate®
storage condition
(Tightly closed)
technique(s)
activity assay: suitable (kinase)
solubility
water: soluble
NCBI accession no.
UniProt accession no.
Quality Level
Gene Information
human ... GSK3B(2932)
Analysis Note
通过磷酸糖原合酶肽2的磷酸化进行常规评估。
Biochem/physiol Actions
糖原合成酶激酶3β(GSK3β)通过胰岛素依赖性通路调节糖原代谢。参与无数信号传导通路，包括细胞周期、细胞增殖和发炎等细胞过程。GSK3β介导胰岛素信号通路的负性调节，最终导致2型糖尿病。GSK3β可作为肿瘤抑制剂，抑制细胞的肿瘤转化。它是Wnt/β-连环蛋白传导通路的关键调节因子。GSK3β调节异常与心血管疾病、双相障碍和神经退行性疾病有关。
General description
糖原合成酶激酶3β(GSK3β)是丝氨酸-苏氨酸类激酶，分布于大部分真核细胞中。GSK3β基因位于人染色体3q13.3。GSK3β由N端β折叠片结构域与C端α螺旋结构域相连而成。
研究领域：细胞信号传导
研究领域：细胞信号传导
Other Notes
比活相关数据，请参阅检验报告以获取该酶的单独批次。
Packaging
也提供250 μg的规格（2x125μg）-订购250 μg的规格时，请致电咨询价格和供货情况，参考目录号14-306M。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
rystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition
Dajani R, et al.
Cell, 105(6), 721-732 (2009)
Jia Luo
Cancer letters, 273(2), 194-200 (2008-07-09)
Glycogen synthase kinase 3beta (GSK3beta), a multifunctional serine/threonine kinase found in all eukaryotes, had been initially identified as a key regulator of insulin-dependent glycogen synthesis. It is now known that GSK3beta functions in diverse cellular processes including proliferation, differentiation, motility
S Phukan et al.
British journal of pharmacology, 160(1), 1-19 (2010-03-25)
Glycogen synthase kinase-3 beta (GSK3beta) is a multifunctional serine/threonine kinase which was originally identified as a regulator of glycogen metabolism. It plays a key role in the regulation of numerous signalling pathways including cellular process such as cell cycle, inflammation
The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro.
Sutherland, C and Cohen, P
Febs Letters, 338, 37-42 (1994)
Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase
Xu, J., et al
The Journal of Biological Chemistry, 278, 26929-26937 (2003)
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