14-306-M
GSK3β 蛋白，活性，10 µg
Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.
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关于此项目
UNSPSC Code:
12352202
NACRES:
NA.26
eCl@ss:
32160405
Form:
liquid
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
Mol wt:
Mw 51 kDa
biological source
human
recombinant
expressed in baculovirus infected Sf21 cells
form
liquid
mol wt
Mw 51 kDa
composition
mercaptoethanol, 0.1-1% , saccharose, 5-10%
manufacturer/tradename
Upstate®
storage condition
(Tightly closed)
technique(s)
activity assay: suitable (kinase)
solubility
water: soluble
NCBI accession no.
UniProt accession no.
Quality Level
Gene Information
human ... GSK3B(2932)
General description
糖原合成酶激酶3β(GSK3β)是丝氨酸-苏氨酸类激酶，分布于大部分真核细胞中。GSK3β基因位于人染色体3q13.3。GSK3β由N端β折叠片结构域与C端α螺旋结构域相连而成。
研究领域：细胞信号传导
研究领域：细胞信号传导
Biochem/physiol Actions
糖原合成酶激酶3β(GSK3β)通过胰岛素依赖性通路调节糖原代谢。参与无数信号传导通路，包括细胞周期、细胞增殖和发炎等细胞过程。GSK3β介导胰岛素信号通路的负性调节，最终导致2型糖尿病。GSK3β可作为肿瘤抑制剂，抑制细胞的肿瘤转化。它是Wnt/β-连环蛋白传导通路的关键调节因子。GSK3β调节异常与心血管疾病、双相障碍和神经退行性疾病有关。
Packaging
也提供250 μg的规格（2x125μg）-订购250 μg的规格时，请致电咨询价格和供货情况，参考目录号14-306M。
Analysis Note
通过磷酸糖原合酶肽2的磷酸化进行常规评估。
Other Notes
比活相关数据，请参阅检验报告以获取该酶的单独批次。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
rystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition
Dajani R, et al.
Cell, 105(6), 721-732 (2009)
S Phukan et al.
British journal of pharmacology, 160(1), 1-19 (2010-03-25)
Glycogen synthase kinase-3 beta (GSK3beta) is a multifunctional serine/threonine kinase which was originally identified as a regulator of glycogen metabolism. It plays a key role in the regulation of numerous signalling pathways including cellular process such as cell cycle, inflammation
The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro.
Sutherland, C and Cohen, P
Febs Letters, 338, 37-42 (1994)
Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase
Xu, J., et al
The Journal of Biological Chemistry, 278, 26929-26937 (2003)
Jia Luo
Cancer letters, 273(2), 194-200 (2008-07-09)
Glycogen synthase kinase 3beta (GSK3beta), a multifunctional serine/threonine kinase found in all eukaryotes, had been initially identified as a key regulator of insulin-dependent glycogen synthesis. It is now known that GSK3beta functions in diverse cellular processes including proliferation, differentiation, motility
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