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Merck
CN

14-347-M

CHK2 Protein, active, 10 µg

Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.

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UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405

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产品名称

CHK2 Protein, active, 10 µg, Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.

biological source

human

recombinant

expressed in E. coli

product line

Upstate®

specific activity

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

mol wt

Mw 89.6 kDa

purified by

(glutathione-agarose and Ni2+/NTA-agarose)

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

accession no.

 (FUNCTION: SwissProt: O96017 # Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on ′Ser-216′, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at ′Thr-18′ and ′Ser-20′. )
NM_001005735.1

NCBI accession no.

NM_001005735.1
NM_007194.3
NM_145862.2

UniProt accession no.

O96017

Quality Level

100

Gene Information

human ... CHEK2(11200)

Analysis Note

routinely evaluated by phosphorylation of the CHKtide substrate peptide

Biochem/physiol Actions

Protein Target: CHK2
Target Sub-Family: CAMK

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

CHK2
Recombinant human CHK2, residues 5-543, containing N-terminal GST and Cterminal His6 tags

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Packaging

Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-347M when ordering the 250 µg size.

Physical form

glutathione-agarose and Ni2+/NTA-agarose

Preparation Note

1 year at -70°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_c

Not applicable

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S Matsuoka et al.
Science (New York, N.Y.), 282(5395), 1893-1897 (1998-12-04)
In response to DNA damage and replication blocks, cells prevent cell cycle progression through the control of critical cell cycle regulators. We identified Chk2, the mammalian homolog of the Saccharomyces cerevisiae Rad53 and Schizosaccharomyces pombe Cds1 protein kinases required for

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