14-347-M
CHK2 Protein, active, 10 µg
Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.
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关于此项目
UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405
Biological source:
human
Mol wt:
Mw 89.6 kDa
biological source
human
Quality Level
Gene Information
human ... CHEK2(11200)
product line
Upstate®
specific activity
(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
mol wt
Mw 89.6 kDa
purified by
(glutathione-agarose and Ni2+/NTA-agarose)
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
accession no.
(FUNCTION: SwissProt: O96017 # Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on ′Ser-216′, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at ′Thr-18′ and ′Ser-20′. ), NM_001005735.1
NCBI accession no.
General description
CHK2
Recombinant human CHK2, residues 5-543, containing N-terminal GST and Cterminal His6 tags
Biochem/physiol Actions
Protein Target: CHK2
Target Sub-Family: CAMK
Packaging
Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-347M when ordering the 250 µg size.
Physical form
glutathione-agarose and Ni2+/NTA-agarose
Preparation Note
1 year at -70°C
Analysis Note
routinely evaluated by phosphorylation of the CHKtide substrate peptide
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_c
Not applicable
S Matsuoka et al.
Science (New York, N.Y.), 282(5395), 1893-1897 (1998-12-04)
In response to DNA damage and replication blocks, cells prevent cell cycle progression through the control of critical cell cycle regulators. We identified Chk2, the mammalian homolog of the Saccharomyces cerevisiae Rad53 and Schizosaccharomyces pombe Cds1 protein kinases required for
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