产品名称
MKK4/SKK1 Protein, active, 10 µg, Active, N-terminal GST tagged, murine MKK4 residues 34-end, for use in Kinase Assays.
biological source
mouse
mol wt
Mw 67.7 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
Gene Information
mouse ... MAP2K4(26398)
Analysis Note
routinely evaluated by phosphorylation of ATF2 substrate
Biochem/physiol Actions
Protein Target: MKK4
Target Sub-Family: STE
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
N-terminal GST tagged, murine MKK4 residues 34-end
Product Source: expressed in E. coli
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Packaging
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-377M when ordering the 250 µg size.
Physical form
Purified using glutathione agarose. Activated by incubation with MEKK and then re-purified using Ni2+/NTA agarose
Preparation Note
6 months at -70C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Y Fleming et al.
The Biochemical journal, 352 Pt 1, 145-154 (2000-11-04)
Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif
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