产品名称
p300，HAT域, Recombinant GST-fusion protein corresponding to amino acids 1066-1707 of human p300.
biological source
human
recombinant
expressed in E. coli
mol wt
Mw 100 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (histone acetyltransferase (HAT))
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Quality Level
Gene Information
human ... EP300(2033)
Analysis Note
通过HAT分析进行常规评估。
Application
与人p300氨基酸1066-1707相对应的重组GST融合蛋白。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
产品来源：在大肠埃希菌中表达。
Other Notes
关于比活相关数据，请参阅该酶单独批次的检验报告。
比活度：1单位定义为1 nmol[3H]-乙酸盐/分钟转移至酸提取的组蛋白。
Preparation Note
自收货之日起，在-20°C下最多保存6个月。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 1
The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.
Weibin Wang,Kewu Pan,Yifan Chen,Chunyin Huang,Xiaowei Zhang
Nucleic Acids Research null
A Giordano et al.
Journal of cellular physiology, 181(2), 218-230 (1999-09-25)
p300 and CBP are highly related nuclear proteins, which have been implicated in transcriptional responses to disparate extracellular and intracellular signals. There are at least two very good reasons for which p300 and CBP have attracted the attention of the
R L Schiltz et al.
The Journal of biological chemistry, 274(3), 1189-1192 (1999-01-09)
A number of transcriptional coactivators possess intrinsic histone acetylase activity, providing a direct link between hyperacetylated chromatin and transcriptional activation. We have determined the core histone residues acetylated in vitro by recombinant p300 and PCAF within mononucleosomes. p300 specifically acetylates
Dennis Shin-Shian Hsu et al.
Cancer cell, 26(4), 534-548 (2014-10-15)
Snail is primarily known as a transcriptional repressor that induces epithelial-mesenchymal transition by suppressing adherent proteins. Emerging evidence suggests that Snail can act as an activator; however, the mechanism and biological significance are unclear. Here, we found that CREB-binding protein
Junhui Xue et al.
Cancer letters, 471, 12-26 (2019-12-08)
Alpha-fetoprotein (AFP) is a well-established biomarker for hepatocellular carcinoma (HCC). Here, we investigated the acetylation state of AFP in vivo. AFP acetylation was regulated by the acetyltransferase CBP and the deacetylase SIRT1. Acetylation of AFP at lysines 194, 211, and
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