14-520-M
Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg
Active, N-terminal, GST-tagged, recombinant human CK1 delta, amino acids 1-294, for use in Kinase Assays.
别名:
Kinase protein
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关于此项目
UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405
Biological source:
human
Recombinant:
expressed in E. coli
biological source
human
recombinant
expressed in E. coli
mol wt
Mw 61 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
Quality Level
Gene Information
human ... CSNK1D(1453)
General description
Research area: Cell signaling
Research Category: Metabolism Research
Subcategory: Obesity
Protein Target: CK1γδ
Target Sub-Family: CK1
Casein Kinase 1δ (CK1δ ) is a serine/threonine kinase that belong to the family of casein kinase 1. The protein structure consists of anti-parallel β-sheet strands at N-terminal lobe (N-lobe) and α-helices and loop structures at the larger C-terminal lobe (C-lobe).
Research Category: Metabolism Research
Subcategory: Obesity
Protein Target: CK1γδ
Target Sub-Family: CK1
Casein Kinase 1δ (CK1δ ) is a serine/threonine kinase that belong to the family of casein kinase 1. The protein structure consists of anti-parallel β-sheet strands at N-terminal lobe (N-lobe) and α-helices and loop structures at the larger C-terminal lobe (C-lobe).
Application
Research Category
Metabolism
Metabolism
Research Sub Category
Obesity
Metabolic Disorders
Obesity
Metabolic Disorders
Biochem/physiol Actions
Casein Kinase 1δ (CK1δ) is implicated in multiple cellular processes, including membrane trafficking, cytokinesis, circadian rhythm, and tumorigenesis. It interacts with critical molecules within cancer-related signaling pathways, such as Wnt/β-catenin, PI3K/AKT, and Hedgehog. Therefore, mutations or overexpression of the CK1δ coding gene can potentially contribute to the onset and progression of cancer.
Packaging
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-520M when ordering the 250 µg size.
Physical form
Glutathione-agarose
Preparation Note
6 months at -20°C
Analysis Note
routinely evaluated by phosphorylation of KRRRALS(p)VASLPGL
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 2
Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)
Xu P, et al.
A Manual for Genetic Engineering: Advanced Bacterial Genetics, 715 (2019)
Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)
Xu P, et al.
Gene: X, 2019-2019 (2019)
Francesca Vena et al.
Molecular cancer therapeutics, 19(8), 1623-1635 (2020-05-21)
Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse is inevitable. While the underlying mechanisms leading to gemcitabine resistance are likely to be multifactorial, there is a strong association between activating
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