产品名称
PIM2 Protein, active, 25 µg, Active, human PIM2 expressed in E. coli, purified using GSH agarose, for use in Kinase Assays.
biological source
human
mol wt
Mw 63.4 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
Quality Level
Gene Information
human ... PIM2(11040)
Analysis Note
routinely evaluated by phosphorylation of PIM2tide
General description
Product Source: N-terminal GST-tagged recombinant full-length human PIM2
human PIM2 expressed in E. coli, purified using GSH agarose
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Physical form
GSH agarose
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Casey J Fox et al.
Genes & development, 17(15), 1841-1854 (2003-07-19)
Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the serine/threonine kinase pim-2. When constitutively expressed, Pim-2 conferred long-term resistance to a variety of apoptotic stimuli
Bin Yan et al.
The Journal of biological chemistry, 278(46), 45358-45367 (2003-09-05)
Hematopoietic growth factors mediate the survival and proliferation of blood-forming cells, but the mechanisms through which these proteins produce their effects are incompletely known. Recent studies have identified the pim family of kinases as mediators of cytokine-dependent survival signals. Several
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