14-629-M
JAK3 Protein, active, 10 µg
Active, N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end, for use in Kinase Assays.
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关于此项目
UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405
Biological source:
human
Mol wt:
Mw 39.9 kDa
biological source
human
Quality Level
product line
Upstate®
specific activity
(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
mol wt
Mw 39.9 kDa
purified by
(Ni2+/NTA-agarose)
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
accession no.
(FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K. ), NM_000215.2
NCBI accession no.
General description
JAK3
N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end
Application
Research Category
Inflammation & Immunology
Inflammation & Immunology
Biochem/physiol Actions
Protein Target: JAK3
Target Sub-Family: TK
Packaging
Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-629M when ordering the 250 µg size.
Physical form
Ni2+/NTA-agarose
Preparation Note
6 months at -70°C
Analysis Note
routinely evaluated by phosphorylation of 500μM JAK3tide (Catalog # 12-547)
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_c
Not applicable
B A Witthuhn et al.
Nature, 370(6485), 153-157 (1994-07-14)
Many cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies have shown that one or more of the Janus kinase family
J A Johnston et al.
Nature, 370(6485), 151-153 (1994-07-14)
Interleukin-2 is an autocrine growth factor for T cells which also activates other cells including B cells and natural killer cells. The subunits of the interleukin-2 receptor (IL-2R) lack intrinsic enzymatic activity, but protein tyrosine phosphorylation is a critical event
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