14-685-M
Cdk9/Cyclin T1 Protein, active, 10 µg
Active, C-terminal 6His-tagged, full length recombinant, human Cdk9 co-expressed with untagged, full-length human Cyclin T1, for use in Kinase Assays.
产品名称
Cdk9/Cyclin T1 Protein, active, 10 µg, Active, C-terminal 6His-tagged, full length recombinant, human Cdk9 co-expressed with untagged, full-length human Cyclin T1, for use in Kinase Assays.
biological source
human
recombinant
expressed in Sf9 cells
mol wt
Mw 44 kDa (cdk9)
Mw 80.79 kDa (cyclinT1)
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
Quality Level
Gene Information
human ... CDK9(1025)
Analysis Note
routinely evaluated by phosphorylation of PDKtide (Catalog# 12-401)
Application
Research Category
Inflammation & Immunology
Inflammation & Immunology
Biochem/physiol Actions
Protein Target: CDK9/cyclin T1
Target Sub-Family: CMGC
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
C-terminal 6His-tagged, fulllength recombinant, human cdk9 co-expressed with untagged, full-length human cyclin T1
Product Source: expressed by baculovirus in Sf21 insect cells
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Physical form
Ni2+/NTA-agarose
Preparation Note
stable for 6 months at -70°C from date of shipment
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cyclins that don't cycle--cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size.
Sano, Motoaki and Schneider, Michael D
Cell Cycle, 2, 99-104 (2003)
Li-Ying Liou et al.
The international journal of biochemistry & cell biology, 36(9), 1767-1775 (2004-06-09)
The macrophage is an important cell type in the pathophysiology of human immunodeficiency virus type 1 (HIV-1) infection. Macrophages both support viral replication and are capable of attracting and activating lymphocytes, thus rendering CD4+ T lymphocytes highly permissive for infection.
Cellular control of gene expression by T-type cyclin/CDK9 complexes.
Garriga, Judit and Gra?a, Xavier
Gene, 337, 15-23 (2004)
Tinggui Yin et al.
Molecular cancer therapeutics, 13(6), 1442-1456 (2014-04-02)
DNA-dependent RNA polymerase II (RNAP II) largest subunit RPB1 C-terminal domain (CTD) kinases, including CDK9, are serine/threonine kinases known to regulate transcriptional initiation and elongation by phosphorylating Ser 2, 5, and 7 residues on CTD. Given the reported dysregulation of
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