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Merck
CN

14-688-M

PKG1α 蛋白，活性 10 µg

Active, N-terminal 6His-tagged, recombinant, full length PKG1α. For use in Kinase Assays.

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UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405

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产品名称

PKG1α 蛋白，活性 10 µg, Active, N-terminal 6His-tagged, recombinant, full length PKG1α. For use in Kinase Assays.

biological source

human

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

Mw 80 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_001098512.1
NM_006258.2

UniProt accession no.

P14619

Quality Level

100

Gene Information

human ... PRKG1(5592)

Analysis Note

通常通过PAKtide（RRRLSFAEPG）的磷酸化进行评估。

Application

研究类别
炎症 & 免疫学

Biochem/physiol Actions

蛋白质靶标：PKG1α
靶标亚家族：AGC

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

N末端6个His标签，重组，全长PKG1α。
产品来源：PKG1α，由杆状病毒在Sf21细胞中表达获得。

Other Notes

比活相关数据，请参阅分析证书以获取该酶的单独批次。

Physical form

Ni2+/NTA-琼脂糖

Preparation Note

自发货之日起可在-70°C保存6个月

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Mary G Johlfs et al.
PloS one, 10(7), e0132105-e0132105 (2015-07-02)
Profiling cellular proteome is critical to understanding signal integration during cell fate determination. In this study, the capability of capillary isoelectric focusing (cIEF) immunoassays to detect post-translational modifications (PTM) of protein isoforms is demonstrated. cIEF immunoassays exhibit protein detection sensitivity
Sequential activation of soluble guanylate cyclase, protein kinase G and cGMP-degrading phosphodiesterase is necessary for proper induction of long-term potentiation in CA1 of hippocampus. Alterations in hyperammonemia.
Monfort, Pilar, et al.
Neurochemistry International, 45, 895-901 (2004)
Modulation of synaptic function by cGMP and cGMP-gated cation channels.
Barnstable, Colin J, et al.
Neurochemistry International, 45, 875-884 (2004)
Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase.
Birschmann, Ingvild and Walter, Ulrich
Acta Biochimica Polonica, 51, 397-404 (2004)
Zhenyu Li et al.
Cell, 112(1), 77-86 (2003-01-16)
It is currently accepted that cGMP-dependent protein kinase (PKG) inhibits platelet activation. Here, we show that PKG plays an important stimulatory role in platelet activation. Expression of recombinant PKG in a reconstituted cell model enhanced von Willebrand factor (vWF)-induced activation

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