生物来源

human

质量水平

100

重组

expressed in baculovirus infected Sf21 cells

产品线

Upstate^®

比活

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

分子量

M_w 59 kDa

纯化方式

(Ni²⁺/NTA-agarose)

种属反应性

human

制造商/商品名称

Upstate^®

技术

activity assay: suitable (kinase)

登记号

 (FUNCTION: SwissProt: P06239 # Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyp)
NM_005356.3

NCBI登记号

NM_005356.3

UniProt登记号

P06239

相关疾病

obesity; metabolic disorders