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Merck
CN

14-902-M

Sigma-Aldrich

AMPK (α2, β1, γ1) Protein, active, 10 µg

Active, recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.

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关于此项目

UNSPSC代码:
12352202
eCl@ss:
32160405
NACRES:
NA.32

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生物来源

human

质量水平

100

重组

expressed in E. coli

产品线

Upstate®

比活

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

分子量

Mw 30 kDa (AMPKß1)
Mw 38 kDa (AMPKγ1)
Mw 63 kDa (AMPKα2)

纯化方式

(Ni2+/NTA-agarose)

种属反应性

human

制造商/商品名称

Upstate®

技术

activity assay: suitable (kinase)

登记号

 (Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5′-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. )
NM_006252

NCBI登记号

NM_002733
NM_006252
NM_006253

UniProt登记号

P54619
P54646
P54646, Q9Y478, P54619
Q9Y478

相关疾病

diabetes; obesity; metabolic disorders

基因信息

human ... PRKAA2(5563), PRKAB1(5563)

一般描述

AMPK (α2, β1, γ1)
Recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 and full length untagged AMPKγ1.

应用

Research Category
Metabolism

Apoptosis & Cancer
Research Sub Category
Diabetes

Obesity

Metabolic Disorders

生化/生理作用

Protein Target: AMPK (α2, β1, γ1)
Target Sub-Family: CAMK

包装

Also available in 10 μg size and in bulk
Also available in 250µg size as catalog # 14-902M - Call for pricing and availability.

外形

Cobalt-agarose

制备说明

6 months at -70°C

分析说明

Routinely evaluated by phosphorylation of substrate peptide

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H317

危险分类

Skin Sens. 1

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°C)

Not applicable

分析证书(COA)

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