AMPK (α2, β1, γ1) Protein, active, 10 µg

产品名称

AMPK (α2, β1, γ1) Protein, active, 10 µg, Active, recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.

biological source

human

recombinant

expressed in E. coli

product line

Upstate^®

specific activity

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

mol wt

M_w 38 kDa (AMPKγ1)
M_w 63 kDa (AMPKα2)
M_w 30 kDa (AMPKβ1)

purified by

(Ni²⁺/NTA-agarose)

species reactivity

human

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

accession no.

 (Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5′-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. )
NM_006252

NCBI accession no.

NM_002733
NM_006252
NM_006253

UniProt accession no.

P54619
P54646
P54646, Q9Y478, P54619
Q9Y478

relevant disease(s)

diabetes; obesity; metabolic disorders

Quality Level

100

Gene Information

human ... PRKAA2(5563), PRKAB1(5563)