CLK4 Protein, active, 10 µg

CLK4 protein belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.

Product Source: N-terminal 6His-tagged, recombinant, human CLK4 amino acids 128-end expressed by baculovirus in Sf21 insect cells.

Research Category
Signaling

Protein Target: CLK4

Target Sub-Family: CMGC

Also available in 250μg size as catalog # 14-917M and in bulk as catalog # 14-917-K.

50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.

Purified using immobilized metal affinity chromatography.

6 months at -70°C

Routinely evaluated by phosphorylation of peptide YRRAAVPPSPSLSRHSSPHQS(p)EDEEE.

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

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