Product Source: N-terminal 6His-tagged, recombinant, human TYK2 amino acids 875-end, expressed by baculovirus in Sf21 insect cells.

TYK2 is member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Research Category
Signaling

Protein Target: TYK2

Target Sub-Family: TK

Also available in 250μg size as catalog # 14-924M and in bulk as catalog # 14-924-K.

Routinely evaluated by phosphorylation of peptide GGMEDIYFEFMGGKKK

Purified using immobilized metal affinity chromatography followed by gel filtration.

50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol

6 months at -70°C

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

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