GRK1, active

Product Source: N-terminal 6His-tagged, recombinant, human GRK1 full length, expressed by baculovirus in Sf21 insect cells

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.

Target Sub-Family: AGC

Also available in 250μg size as catalog # 14-935M and in bulk as catalog # 14-935-K.

Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

Purified using immobilized metal affinity chromatography.

6 months at -70°C

Routinely evaluated by phosphorylation of KKKKERLLDDRHDSGLDSMKDEE

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

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