16-233
Anti-FAK Antibody, clone 4.47, Alexa Fluor™ 488 conjugate
clone 4.47, Upstate®, from mouse
别名:
Anti-FADK, Anti-FADK 1, Anti-FAK, Anti-FAK1, Anti-FRNK, Anti-PPP1R71, Anti-p125FAK, Anti-pp125FAK
生物来源
mouse
质量水平
偶联物
ALEXA FLUOR™ 488
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
4.47, monoclonal
种属反应性
human, rat, mouse
制造商/商品名称
Upstate®
技术
flow cytometry: suitable
immunocytochemistry: suitable
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... PTK2(5747)
一般描述
125kDa
免疫原
GST fusion protein corresponding to residues 1-423 of human FAK (focal adhesion kinase)
应用
Detect FAK using this Anti-FAK Antibody, clone 4.47, Alexa Fluor 488 conjugate validated for use in FC, WB & IC.
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
生化/生理作用
p125FAK, does not cross react with Pyk-2
外形
Protein G Purified
制备说明
1 year at 4°C from date of shipment
分析说明
Routinely evaluated by immunostaining of 3T3 cells.
法律信息
ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Focal adhesion kinase: the first ten years.
Parsons, J Thomas
Journal of Cell Science, 116, 1409-1416 (2003)
Julia Meller et al.
JCI insight, 2(11) (2017-06-02)
Microglia play a critical role in the development and homeostasis of the CNS. While mobilization of microglia is critical for a number of pathologies, understanding of the mechanisms of their migration in vivo is limited and often based on similarities
Control of motile and invasive cell phenotypes by focal adhesion kinase.
Schlaepfer, David D, et al.
Biochimica et Biophysica Acta, 1692, 77-102 (2004)
David D Schlaepfer et al.
Current opinion in genetics & development, 14(1), 92-101 (2004-04-28)
The ability of intracellular signaling networks to orchestrate a complex biological response such as cell motility requires that individual signaling proteins must act as integrators, responding to multiple extracellular inputs and regulating multiple signaling pathway outputs. In this review, we
FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
Schaller, Michael D
The Journal of cell biology, 166, 157-159 (2004)
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