biological source
mouse
Quality Level
conjugate
ALEXA FLUOR™ 488
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
LA1, monoclonal
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
immunofluorescence: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... EGFR(1956)
mouse ... Egfr(13649)
rat ... Egf(25313)
General description
Included Negative Control: Catalog # 16-240, Alexa Fluor™ 488-conjugated Normal Mouse IgG.
Inhibits A431 cell growth. Recognizes an antigenic determinant located on the extracellular domain of the receptor.
Inhibits A431 cell growth. Recognizes an antigenic determinant located on the extracellular domain of the receptor.
Immunogen
Human A431 membrane proteins
Application
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
This Anti-EGFR Antibody, neutralizing, clone LA1, Alexa Fluor 488 is validated for use in IF for the detection of EGFR.
Biochem/physiol Actions
external domain of EGF receptor on all human cells. Competes with EGF and TGF-α for binding on human cells. Recognizes both phosphorylated and non-phosphorylated human EGF receptors.
Preparation Note
1 year at 4°C from date of shipment
Analysis Note
Routinely evaluated by positive immunostaining for the EGF receptor in A431 cells.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Matthew J Crow et al.
AJR. American journal of roentgenology, 192(4), 1021-1028 (2009-03-24)
The goal of this study was to assess whether immunolabeled nanoparticle biomarkers are comparable to fluorescent marker imaging in measuring epidermal growth factor receptor (EGFR) expression. EGFR expression was quantified using both imaging methods in four cell lines: A431 human
Cetuximab.
Goldberg, Richard M
Nature Reviews. Drug Discovery, Suppl, S10-S11 (2005)
Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy.
Bianco, Roberto, et al.
Endocrine-Related Cancer, 12 Suppl 1, S159-S171 (2005)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 16-246 | 04053252410642 |