164610
p-Aminophenylmercuric Acetate
≥90% (HPLC), MMP activator, solid
别名:
p-Aminophenylmercuric Acetate, APMA
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关于此项目
经验公式（希尔记法）:
C8H9HgNO2
化学文摘社编号:
分子量:
351.75
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
p-Aminophenylmercuric Acetate, An organomercurial agent used for the activation of latent MMPs in vitro. Acts by facilitating the loss of the enzyme propeptide domain through an autolytic cleavage known as the cysteine switch.
Quality Level
description
RTECS - OV5550000
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
yellow
solubility
0.1 M NaOH: 10 mg/mL, DMSO: 10 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
[Hg+]c1ccc(cc1)N.[O-]C(=O)C
InChI
1S/C6H6N.C2H4O2.Hg/c7-6-4-2-1-3-5-6;1-2(3)4;/h2-5H,7H2;1H3,(H,3,4);/q;;+1/p-1
InChI key
RXSUFCOOZSGWSW-UHFFFAOYSA-M
General description
An organomercurial agent used for the activation of latent matrix metalloproteinases (MMPs) in vitro. Acts by facilitating the loss of the enzyme propeptide domain through an autolytic cleavage known as the cysteine switch.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Activation of latent MMPs in vitro
Activation of latent MMPs in vitro
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Other Notes
Chen, J.-M., et al. 1991. J. Biol. Chem. 266, 5113.
Marcy, A.I., et al. 1991. Biochemistry30, 6476.
Stricklin, G.P., et al. 1983. Biochemistry22, 61.
Marcy, A.I., et al. 1991. Biochemistry30, 6476.
Stricklin, G.P., et al. 1983. Biochemistry22, 61.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.
Toxicity: Highly Toxic (H)
signalword
Danger
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Saskia V Vijver et al.
Frontiers in immunology, 12, 733561-733561 (2021-10-26)
The tumor microenvironment (TME) is a complex structure comprised of tumor, immune and stromal cells, vasculature, and extracellular matrix (ECM). During tumor development, ECM homeostasis is dysregulated. Collagen remodeling by matrix metalloproteinases (MMPs) generates specific collagen fragments, that can be
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 164610-1SET | 04055977207620 |
| 164610-700MG | 04055977207637 |