165304
D-(–)-2-氨基-5-膦酰戊酸
≥97% (HPLC), solid, NMDA receptor antagonist, Calbiochem®
别名:
D-(–)-2-氨基-5-膦酰戊酸, D-AP5，NMDA拮抗剂II，APV，D-APV，2-APV，D-2-氨基-5-磷酸戊酸
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关于此项目
经验公式（希尔记法）:
C5H12NO5P
化学文摘社编号:
分子量:
197.13
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
产品名称
D-(–)-2-氨基-5-膦酰戊酸, Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used as a competitive NMDA receptor antagonist.
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
dilute aqueous base: 1 mg/mL, water: 1 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[P](=O)([O-])([O-])CCC[C@@H]([N+H3])C(=O)[O-]
InChI
1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/p-2/t4-/m1/s1
InChI key
VOROEQBFPPIACJ-SCSAIBSYSA-L
General description
一种DL-2-氨基-5-膦基戊酸（AP5）的活性对映体，通常用作竞争性NMDA受体拮抗剂。还抑制辣椒素诱导的脊髓物质P的释放。
Biochem/physiol Actions
主要靶标
NMDA受体拮抗剂
NMDA受体拮抗剂
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。
Other Notes
Malcangio, M., et al. 1998.Br. J. Pharmacol.125, 1625.
Schulte, M.K., et al. 1994.Brain Res. 649, 203.
Davis, S., et al. 1992.J. Neurosci. 12, 21.
Schulte, M.K., et al. 1994.Brain Res. 649, 203.
Davis, S., et al. 1992.J. Neurosci. 12, 21.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable