171261
Dorsomorphin
≥95% (HPLC), liquid, AMPK inhibitor, Calbiochem
别名:
InSolution AMPK抑制剂，化合物C
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关于此项目
经验公式（希尔记法）:
C24H25N5O
化学文摘社编号:
分子量:
399.49
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze
desiccated (hygroscopic)
protect from light
desiccated (hygroscopic)
protect from light
产品名称
AMPK抑制剂，化合物C, InSolution, ≥95%, 10 mM, AMPK Inhibitor
SMILES string
[n]21ncc(c2ncc(c1)c4ccc(cc4)OCCN5CCCCC5)c3ccncc3
InChI
1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
InChI key
XHBVYDAKJHETMP-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Physical form
提供 10 mM（1 mg/250 µl）的 AMPK 抑制剂，化合物 C（货号171260），溶剂为DMSO
Preparation Note
初次使用后，等分并冷冻（-20°C）。一旦打开，储备溶液在 -20°C 下可稳定保存 3 个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Hao, J., et al. 2010.ACS Chem.Biol.5, 245.
Kim, E.K., et al. 2004.J. Biol. Chem.279, 19970.
Lee, M., et al. 2003.J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003.Cell115, 577.
Fryer, L.G., 2002.FEBS Lett.531, 189.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.
Kim, E.K., et al. 2004.J. Biol. Chem.279, 19970.
Lee, M., et al. 2003.J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003.Cell115, 577.
Fryer, L.G., 2002.FEBS Lett.531, 189.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.
Packaging
用惰性气体包装
Biochem/physiol Actions
主要靶标
AMPK
AMPK
产物与ATP竞争。
可逆性：是
细胞可渗透性：具有
阻断斑马鱼活体胚胎中BMP途径依赖性背腹发育的EC100 = 2.5 µM；阻断VEGF信号转导依赖性肌间血管形成的EC50 = 5 µM
靶标IC50：抑制KDR/VEGFR2、ALK2/BMPR-1、AMPK激酶活性分别为25.1、148和234.6 nM
Disclaimer
毒性：刺激性（B）
General description
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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