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171261

Dorsomorphin

Name: Dorsomorphin
Brand: MM

≥95% (HPLC), liquid, AMPK inhibitor, Calbiochem

别名:

InSolution AMPK抑制剂，化合物C

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关于此项目

经验公式（希尔记法）:

C₂₄H₂₅N₅O

化学文摘社编号:

866405-64-3

分子量:

399.49

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD08705402

Assay:

≥95% (HPLC)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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属性

产品名称

AMPK抑制剂，化合物C, InSolution, ≥95%, 10 mM, AMPK Inhibitor

Quality Level

100

assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[n]21ncc(c2ncc(c1)c4ccc(cc4)OCCN5CCCCC5)c3ccncc3

InChI

1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

InChI key

XHBVYDAKJHETMP-UHFFFAOYSA-N

说明

General description

一种细胞可透过性吡唑并嘧啶化合物，可抑制KDR/VEGFR2、ALK2/BMPR-1、AMPK激酶活性（IC₅₀ = 25.1、148和234.6 nM），而对对ALK5/TGFβR-I、ZAPK、Syk、PKCθ、PKA或JAK3的作用却大大降低或几乎没有。研究表明，可阻断斑马鱼活体胚胎中BMP途径依赖性背腹发育（EC₁₀₀ = 2.5 µ）和VEGF信号转导依赖性肌间血管形成（EC₅₀ = 5 µM）。通常与 AMPK 激活剂 AICAR（货号 123040）和/或二甲双胍（货号 317240）结合使用，以研究 AMPK 依赖性细胞事件在体外和动物体内的生理反应。

Biochem/physiol Actions

主要靶标
AMPK

产物与ATP竞争。

可逆性：是

细胞可渗透性：具有

阻断斑马鱼活体胚胎中BMP途径依赖性背腹发育的EC100 = 2.5 µM；阻断VEGF信号转导依赖性肌间血管形成的EC50 = 5 µM

靶标IC₅₀：抑制KDR/VEGFR2、ALK2/BMPR-1、AMPK激酶活性分别为25.1、148和234.6 nM

Packaging

用惰性气体包装

Physical form

提供 10 mM（1 mg/250 µl）的 AMPK 抑制剂，化合物 C（货号171260），溶剂为DMSO

Preparation Note

初次使用后，等分并冷冻（-20°C）。一旦打开，储备溶液在 -20°C 下可稳定保存 3 个月。

Other Notes

Hao, J., et al. 2010.ACS Chem.Biol.5, 245.
Kim, E.K., et al. 2004.J. Biol. Chem.279, 19970.
Lee, M., et al. 2003.J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003.Cell115, 577.
Fryer, L.G., 2002.FEBS Lett.531, 189.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：刺激性（B）

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

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全球贸易项目编号

货号	GTIN
171261-1MG	04055977207170