171261
Dorsomorphin
≥95% (HPLC), liquid, AMPK inhibitor, Calbiochem
别名:
InSolution AMPK抑制剂，化合物C
产品名称
AMPK抑制剂，化合物C, InSolution, ≥95%, 10 mM, AMPK Inhibitor
质量水平
方案
≥95% (HPLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
运输
wet ice
储存温度
2-8°C
SMILES字符串
[n]21ncc(c2ncc(c1)c4ccc(cc4)OCCN5CCCCC5)c3ccncc3
InChI
1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
InChI key
XHBVYDAKJHETMP-UHFFFAOYSA-N
一般描述
生化/生理作用
主要靶标
AMPK
AMPK
产物与ATP竞争。
可逆性：是
细胞可渗透性：具有
阻断斑马鱼活体胚胎中BMP途径依赖性背腹发育的EC100 = 2.5 µM；阻断VEGF信号转导依赖性肌间血管形成的EC50 = 5 µM
靶标IC50：抑制KDR/VEGFR2、ALK2/BMPR-1、AMPK激酶活性分别为25.1、148和234.6 nM
包装
用惰性气体包装
外形
提供 10 mM（1 mg/250 µl）的 AMPK 抑制剂，化合物 C（货号171260），溶剂为DMSO
制备说明
初次使用后，等分并冷冻（-20°C）。一旦打开，储备溶液在 -20°C 下可稳定保存 3 个月。
其他说明
Hao, J., et al. 2010.ACS Chem.Biol.5, 245.
Kim, E.K., et al. 2004.J. Biol. Chem.279, 19970.
Lee, M., et al. 2003.J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003.Cell115, 577.
Fryer, L.G., 2002.FEBS Lett.531, 189.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.
Kim, E.K., et al. 2004.J. Biol. Chem.279, 19970.
Lee, M., et al. 2003.J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003.Cell115, 577.
Fryer, L.G., 2002.FEBS Lett.531, 189.
Zhou, G., et al. 2001.J. Clin. Invest.108, 1167.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：刺激性（B）
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
闪点(°C)
87 °C - closed cup - (Dimethylsulfoxide)
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