171601
淀粉样肽前体蛋白 β-分泌酶抑制剂
The Amyloid Precursor Protein β-Secretase Inhibitor controls the biological activity of Amyloid Precursor Protein β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
别名:
淀粉样肽前体蛋白 β-分泌酶抑制剂
assay
≥98% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
solubility
aqueous buffer, pH 7.5: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
淀粉样前体蛋白（APP）β-分泌酶的有效抑制剂（IC50=30 nM）。
Biochem/physiol Actions
主要靶标
APP
APP
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：30 nM，针对淀粉样前体蛋白（APP）β-分泌酶
Physical form
作为三氟乙酸盐提供。
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
Other Notes
H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]
Sinha, S., et al. 1999.Nature 402, 537.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Zhi-Hao Wang et al.
Progress in neurobiology, 202, 102032-102032 (2021-03-16)
ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-β (Aβ) metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its pathogenesis via Aβ-dependent and -independent pathways. C/EBPβ, a proinflammatory cytokines-activated transcription factor, is upregulated in AD
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