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176708

Angiostatin K1-3, Human, Recombinant, E. coli

Name: Angiostatin K1-3, Human, Recombinant, <i>E. coli</i>
Brand: MM

Angiostatin K1-3 is a recombinant form expressed in E. coli as a single, non-glycosylated polypeptide chain of 259 amino acids. A specific inhibitor of endothelial cell growth and angiogenesis.

别名:

Ang K1-3, K1-3, rHuAng K1-3

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关于此项目

NACRES:

NA.77

UNSPSC Code:

12352203

Form:

lyophilized powder

Assay:

≥95% (HPLC and SDS-PAGE)

Recombinant:

expressed in E. coli

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属性

recombinant

expressed in E. coli

Quality Level

100

assay

≥95% (HPLC and SDS-PAGE)

form

lyophilized powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

solubility

aqueous buffer containing 0.1% BSA: soluble, water: soluble

shipped in

wet ice

storage temp.

−20°C

说明

General description

Recombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀=70 nM) relative to kringles 1-4 (ED₅₀=135 nm).

Physical form

Lyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA96, 5728.
Cao, E., et al. 1997. J. Biol. Chem.272, 22924.
Sim, B.K., et al. 1997. Cancer Res.57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun.236, 651.
O′Rieilly, M.S., et al. 1994. Cell79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem.265, 6104.
Forsgren, M., et al. 1987. FEBS Lett.213, 254.
Malinowski, D.P., et al. 1984. Biochemistry23, 4243.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

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全球贸易项目编号

货号	GTIN
176708-250UG	04055977222968