Angiotensin Converting Enzyme, His Tag , Human, Recombinant, NSO Cells

Recombinant, human ACE ectodomain (amino acids 30-1261) fused at the C-terminus to a HIS TAG^® sequence and expressed in NSO cells. ACE is a zinc metallopeptidase that cleaves the C-terminal dipeptide from angiotensin I to produce the potent vasopressor octapeptide angiotensin II. ACE gene polymorphism has been a recent topic in Alzheimer′s disease studies. ACE is a type I membrane protein and exists in two isoforms, somatic and germinal. By SDS-PAGE, the apparent molecular weight of the glycosylated protein appears larger to be than 120 kDa under both reducing and non-reducing conditions.

HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany