178223
Antipain, Dihydrochloride
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.
别名:
Antipain, Dihydrochloride
登录并加购，请在购物车里查看协议价、货期和发货地。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C27H44N10O6 · 2HCl
化学文摘社编号:
分子量:
677.62
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
description
RTECS - YV9350800
assay
≥97% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 1 mg/mL, DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Cl-].[Cl-].N([C@@H](C(C)C)C(=O)NC(=O)[C@@H](NC(=O)NC(Cc1ccccc1)C(=O)O)CCCN=C(N)N)C(CCCN=C(N)N)C=O.[H+].[H+]
InChI
1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1
InChI key
GXQPAKIVOCLCHD-BXLPLHKWSA-N
General description
A reversible protease inhibitor produced by actinomycetes. Inhibits cathepsin A and B as well as papain, and trypsin-like serine proteases. Acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 µM.
Effective concentration: 1-100 µM.
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
trypsin-like serine proteases, papain, and some cysteine proteases
trypsin-like serine proteases, papain, and some cysteine proteases
Product does not compete with ATP.
Reversible: yes
Target IC50: 300 µM against trypsin-like serine proteases, papain and some cysteine proteases; Effective concentration: 1-100 µM
Preparation Note
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Other Notes
Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Ichikawa, S., et al. 1985. J. Reprod. Fertil.73, 385
Umezawa, H. 1976. Methods Enzymol.55, 678.
Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
Ichikawa, S., et al. 1985. J. Reprod. Fertil.73, 385
Umezawa, H. 1976. Methods Enzymol.55, 678.
Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Still not finding the right product?
Explore all of our products under Antipain, Dihydrochloride
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable