178273
阿非迪霉素
≥98% (HPLC), solid, DNA polymerase α and δ inhibitor, Calbiochem
别名:
阿非迪霉素
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关于此项目
经验公式（希尔记法）:
C20H34O4
化学文摘社编号:
分子量:
338.48
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
阿非迪霉素, Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase.
SMILES string
O[C@]1([C@H]2C[C@@]3([C@@]4([C@H]([C@@]([C@@H](CC4)O)(CO)C)CC[C@H]3C2)C)CC1)CO
InChI
1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChI key
NOFOAYPPHIUXJR-APNQCZIXSA-N
description
Merck USA index - 14, 727
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 50 mg/mL
ethanol: soluble
methanol: soluble
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
主要靶标
DNA聚合酶α，DNA聚合酶 δ
DNA聚合酶α，DNA聚合酶 δ
产品不与ATP竞争。
可逆：否
细胞渗透性：是
Disclaimer
毒性：标准处理（A）
General description
细胞可透过性四环二萜抗生素，可作为细胞同步化试剂。将细胞周期阻滞在S期早期。真核细胞和某些病毒DNA聚合酶α和δ的特异性抑制剂。可增强白血病细胞系中阿拉伯糖核苷诱导的细胞凋亡。还可诱导HeLa S3细胞凋亡，但会抑制长春新碱诱导人p53阴性前列腺癌细胞系PC-3凋亡的作用。也可以30 mM的DMSO溶液（货号504744）提供。
Other Notes
Borner, M.M., et al. 1995.Cancer Res.55, 2122.
Poluha, W., et al. 1995.Oncogene 10, 185.
Urbani, L., et al. 1995.Exp.Cell Res. 219, 159.
Schimke, R.T., et al. 1994.Philos.Trans.R. Soc.London.B. Biol. Sci.345, 311.
Kuwakado, K., et al. 1993.Biochem.Pharmacol.46, 1909.
Hubermann, J.A.1981.Cell23, 647.
Poluha, W., et al. 1995.Oncogene 10, 185.
Urbani, L., et al. 1995.Exp.Cell Res. 219, 159.
Schimke, R.T., et al. 1994.Philos.Trans.R. Soc.London.B. Biol. Sci.345, 311.
Kuwakado, K., et al. 1993.Biochem.Pharmacol.46, 1909.
Hubermann, J.A.1981.Cell23, 647.
Preparation Note
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存2个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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