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Merck
CN

178281

p-APMSF hydrochloride

≥97% (HPLC), irreversible trypsin-like serine proteases inhibitor, solid

别名:

p-APMSF, Hydrochloride, p-Amidinophenylmethylsulfonylfluoride, HCl

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关于此项目

化学文摘社编号:
74938-88-8
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00078902

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产品名称

p-APMSF, Hydrochloride, Alternative to DFP and PMSF.

SMILES string

F[S](=O)(=O)Cc1ccc(cc1)\C(=N\[H])\N.Cl

InChI

1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H

InChI key

KHLLRHIUKOJXLL-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

white

solubility

water: 25 mg/mL

shipped in

ambient

Quality Level

100

相关类别

General description

Alternative to DFP and PMSF. An irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentration. Acts on C1r, C1s, Factor Xa, and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF.
An alternative to DFP and PMSF. Specific irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentrations. Acts on C1r, C1s, Factor Xa and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF. Stability is pH dependent: t½ = 20 min at pH 6.0; 6 min at pH 7.0; 1 millisecond at pH 8.0.

Biochem/physiol Actions

Cell permeable: no
Primary Target
trypsin-like serine proteases
Product does not compete with ATP.
Reversible: no

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Cole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
Laura, R., et al. 1980. Biochemistry19, 4859.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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