178385
夹竹桃麻素
≥98% (GC), powder, NADPH oxidase inhibitor, Calbiochem®
别名:
夹竹桃麻素, 4-羟基-3-甲氧基苯乙酮，乙酰香草醛，NADPH氧化酶抑制剂V，NOX抑制剂V
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关于此项目
Assay:
≥98% (GC)
Form:
powder
Storage condition:
OK to freeze, protect from light
产品名称
夹竹桃麻素, A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.
Quality Segment
description
Merck USA index - 14, 741
assay
≥98% (GC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white to brown
solubility
DMSO: 10 mg/mL, ethanol: 20 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
O(C)c1c(ccc(c1)C(=O)C)O
InChI
1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3
InChI key
DFYRUELUNQRZTB-UHFFFAOYSA-N
General description
一种细胞可透过性抗炎酚类化合物，可作为 NADPH 氧化酶的有效和选择性抑制剂。研究表明，可阻断鼠巨噬细胞中过亚硝酸盐的形成。据报道，可通过激活 AP-1 增加谷胱甘肽的合成。还有有报道表明，可防止巨噬细胞（10 mM）吞噬髓磷脂。
Biochem/physiol Actions
主靶
NADPH 氧化酶
NADPH 氧化酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
Packaging
用惰性气体包装
Preparation Note
重悬后，等分并冷冻（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。
Other Notes
Abid, M.R., et al. 2000.FEBS Lett.486, 252.
Muijsers, R.B., et al. 2000.Br. J. Pharmacol.130, 932.
Lapperre, T.S., et al. 1999.FEBS Lett.443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol.87, 776.
van der Goes, A., et al. 1998.J. Neuroimmunol.92, 67.
Hart, B.A., and Simmons, J.M.1992.Biotechnol.Ther.3, 3.
Muijsers, R.B., et al. 2000.Br. J. Pharmacol.130, 932.
Lapperre, T.S., et al. 1999.FEBS Lett.443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol.87, 776.
van der Goes, A., et al. 1998.J. Neuroimmunol.92, 67.
Hart, B.A., and Simmons, J.M.1992.Biotechnol.Ther.3, 3.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2