178494
Apoptosis Inhibitor II, NS3694
The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
别名:
Apoptosis Inhibitor II, NS3694, NS3694
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关于此项目
经验公式（希尔记法）:
C15H10ClF3N2O3
化学文摘社编号:
分子量:
358.70
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Apoptosis Inhibitor II, NS3694, The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
SMILES string
FC(F)(F)c1cc(ccc1)NC(=O)Nc2c(ccc(c2)Cl)C(=O)O
InChI
1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)
InChI key
GNCZTZCPXFDPLI-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 10 mg/mL
ethanol: slightly soluble
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Apoptosome complex formation
Apoptosome complex formation
Product does not compete with ATP.
Reversible: no
Target IC50: 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable diarylurea compound that specifically prevents the formation of the active ~700 kDa apoptosome complex induced by cytochrome c release. Alters cytochrome c and ATP-triggered association between Apaf-1 and caspase-9. Protects against apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by Fas ligand (FasL). Does not inhibit cytochrome c release or the activity of caspase-3 and -9.
Other Notes
Lademann, U., et al. 2003. Mol. Cell. Biol.23, 7829.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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