178496
Apoptosis Activator VI, CD437/AHPN
The Apoptosis Activator VI, CD437/AHPN, also referenced under CAS 125316-60-1, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
别名:
Apoptosis Activator VI, CD437/AHPN, 6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid
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关于此项目
经验公式（希尔记法）:
C27H26O3
化学文摘社编号:
分子量:
398.49
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
Oc1c(cc(cc1)c5cc6c(cc(cc6)C(=O)O)cc5)C32CC4CC(C3)CC(C2)C4
InChI
1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)
InChI key
LDGIHZJOIQSHPB-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 39 mg/mL, ethanol: 39 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 months at -20°C.
Other Notes
Watanabe, Y., et al. 2008. Biochem. Biophys. Res. Comm.366, 840.
Holmes, W.F., et al. 2004. J. Cell. Physiol.199, 317.
Zhao, X., and Spanjaard, R.A. 2003. J. Biomed. Sci.10, 44.
Holmes, W.F., et al. 2004. J. Cell. Physiol.199, 317.
Zhao, X., and Spanjaard, R.A. 2003. J. Biomed. Sci.10, 44.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jacob Paiano et al.
Genes & development, 35(19-20), 1356-1367 (2021-09-11)
Double-strand break (DSB) repair choice is greatly influenced by the initial processing of DNA ends. 53BP1 limits the formation of recombinogenic single-strand DNA (ssDNA) in BRCA1-deficient cells, leading to defects in homologous recombination (HR). However, the exact mechanisms by which
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