19-144
佛波醇12-十四酸酯13-乙酸酯，1MG
≥99% (HPLC), solid, PKC activator, Upstate®
别名:
12-O-十四烷酰佛波醇13-乙酸酯, 4β,9α,12β,13α,20-五羟基噻吩-1,6-二烯-3-酮12-十四烷酸酯13-乙酸酯, PMA, TPA
一般描述
光稳定剂12-肉豆蔻酸 13-乙酸酯（PMA）取自未熟的乌桕果实。它是一种促炎剂 。PMA通过释放细胞因子、烟酰胺腺嘌呤二核苷酸磷酯（NADPH）氧化酶和蛋白酶来产生作用，从而导致组织损伤或激活组胺的产生。这会促进血管重塑、发热和发红。PMA具有抗菌、增殖、抗增生和抗肿瘤作用。
应用
佛波醇12-肉豆蔻酸酯13-乙酸酯可用作单核细胞系如 U937 和THP-1细胞分化的诱导剂。
生化/生理作用
佛波醇12-肉豆蔻酸酯13-乙酸酯是一种促肿瘤佛波酯。它通过激活蛋白激酶C（PKC）信号途径来调节各种过程，如基因转录、细胞生长和分化、凋亡、免疫反应和受体脱敏。它促进人单核细胞THP-1细胞分化为功能性巨噬细胞。
外形
C36H56O8
制备说明
在-20°C下可保存2年
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
警示用语：
Danger
危险分类
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Agnes Schröder et al.
Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie (2022-04-22)
Orthodontic tooth movement is a complex process involving the remodeling of extracellular matrix and bone as well as inflammatory processes. During orthodontic treatment, sterile inflammation and mechanical loading favor the production of receptor activator of NF-κB ligand (RANKL). Simultaneously, expression of
Takahide Kohro et al.
Journal of atherosclerosis and thrombosis, 11(2), 88-97 (2004-05-22)
In order to characterize the monocytic cell line THP-1 and its mature, macrophage-like form treated with phorbol 12-myristate 13-acetate (PMA), we have conducted an oligonucleotide microarray assay and compared the results with those from an assay of human monocytes and
Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways.
Chang, et al.
Cellular Signalling, 17, 299-310 (2018)
Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1?-NF-?B Crosstalk In Vitro and In Vivo
Sukkum N C, et al.
International Journal of Molecular Sciences, 21(23), 9261-9261 (2020)
In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1.
Blumberg, P M
Critical Reviews in Toxicology, 8, 153-197 (1980)
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