质量水平
方案
≥94% (HPLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
运输
dry ice
储存温度
−20°C
InChI
1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
InChI key
NTSBZVCEIVPKBJ-UHFFFAOYSA-N
一般描述
A Kenpaullone (>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.
生化/生理作用
Cell permeable: yes
Primary Target
GSK-3β
GSK-3β
Reversible: yes
Target IC50: 18 nM for GSK-3&beta
包装
Packaged under inert gas
外形
A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.
制备说明
Following initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.
其他说明
Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
188.6 °F - closed cup - (refers to pure substance)
闪点(°C)
87 °C - closed cup - (refers to pure substance)
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