196000
Bafilomycin A1
from Streptomyces griseus, ≥90% (HPLC), film, V-ATPase inhibitor
别名:
巴弗洛霉素A1，灰色链霉菌
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关于此项目
经验公式（希尔记法）:
C35H58O9
化学文摘社编号:
分子量:
622.83
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
巴弗洛霉素A1，灰色链霉菌,
SMILES string
O1[C@@H]([C@H]([C@@H](C[C@]1(O)[C@H]([C@H](O)[C@@H]([C@H]2OC(=O)\C(=C\C(=C\[C@H]([C@H]([C@H](C\C(=C\C=C\[C@@H]2OC)\C)C)O)C)\C)\OC)C)C)O)C)C(C)C
InChI
1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChI key
XDHNQDDQEHDUTM-JQWOJBOSSA-N
Quality Level
assay
≥90% (HPLC)
form
film
shelf life
3 yr
storage condition
OK to freeze, protect from light
solubility
DMSO: 100 μM, ethanol: soluble
storage temp.
−20°C
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General description
一种大环内酯类抗生素，可作为液泡型H+-ATP酶（V型； Ki = 500 pM）的特异性抑制剂。区分不同类型ATP酶的有价值的工具。阻断巨噬细胞溶酶体胆固醇的转运，干扰脑细胞的pH调节。在细胞活力测定中，对多种细胞具有细胞毒性作用。据报道，可选择性地抑制β-分泌酶，这是一种参与淀粉样蛋白前体蛋白（APP）加工的酶。另提供HPLC法测定纯度≥97％、90％ DMSO溶解的InSolution形式（货号508409）。
注意：1套 = 3 x 10 µg
Biochem/physiol Actions
主要靶标
空泡型H+ ATP酶
空泡型H+ ATP酶
Preparation Note
溶解后，等分并冷冻保存（-20°C）。DMSO储备溶液在-20°C下可稳定保存1年。
Other Notes
Sinha, S., and Lieberburg, I. 1999.Proc.Natl.Acad.Sci. USA96, 11049.
Calvert, C.M., and Sanders, D. 1995.J. Biol. Chem.270, 7272.
Nishihara, T., et al. 1995.Biochem.Biophys.Res. Commun.269, 255.
Crider, B.P., et al. 1994.J. Biol. Chem.269, 17379.
Palokangas, H., et al. 1994.J. Biol. Chem.269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994.J. Bone Miner.Res.9, 1575.
Drose, S., et al. 1993.Biochemistry32, 3902.
Furuchi, T., et al. 1993.J. Biol. Chem.268, 27345.
Bowman, E.J., et al. 1988.Proc.Natl.Acad.Sci. USA85, 7972.
Calvert, C.M., and Sanders, D. 1995.J. Biol. Chem.270, 7272.
Nishihara, T., et al. 1995.Biochem.Biophys.Res. Commun.269, 255.
Crider, B.P., et al. 1994.J. Biol. Chem.269, 17379.
Palokangas, H., et al. 1994.J. Biol. Chem.269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994.J. Bone Miner.Res.9, 1575.
Drose, S., et al. 1993.Biochemistry32, 3902.
Furuchi, T., et al. 1993.J. Biol. Chem.268, 27345.
Bowman, E.J., et al. 1988.Proc.Natl.Acad.Sci. USA85, 7972.
Disclaimer
毒性：致癌/致畸（D）
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
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